Line two rimmed baking sheets with foil (jelly roll pans or shallow roasting pans).
In a large bowl, combine the ground beef, 1/4 cup ketchup, breadcrumbs, egg, minced onion, garlic powder, black pepper, and salt. Mix lightly but thoroughly and then shape into 1-inch meatballs.
Arrange the meatballs in the prepared pans. Bake the meatballs for 20 minutes, or until they are nicely browned.
Transfer the meatballs to slow cooker.
Mix remaining 1 cup ketchup, brown sugar, tomato paste, soy sauce, vinegar, liquid smoke, and crushed pepper in a medium bowl. Pour the sauce mixture over the meatballs.
Cover and cook on LOW 3 to 4 hours.
Serve with small plates and cocktail picks or toothpicks.